Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Serum IFI16 level in the prediction of preeclampsia

Tong Dong, Wen Jiang, Xiaoning Jia, Mei Xing, Yuhang Zhou, Shande Yin, Lei Chen

1Department of Obstetrics and Gynecology, Navy General Hospital, Beijing, China.;

For correspondence:- Lei Chen Email: kj85785@126.com Tel:+8613212089131

Accepted: 23 April 2021 Published: 31 December 2021

Citation: Dong T, Jiang W, Jia X, Xing M, Zhou Y, Yin S, et al. Serum IFI16 level in the prediction of preeclampsia. Trop J Pharm Res 2021; 20(12):2581-2585 doi: 10.4314/tjpr.v20i12.18

© 2021 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To explore the correlation between serum Interferon Gamma Inducible Protein 16 (IFI16) and preeclampsia (PE), and to study the value of IFI16 in predicting preeclampsia.

Methods: 100 pregnant women with preeclampsia from February 2015 to October 2017 were chosen for experiments, simultaneously, 75 healthy pregnant women who underwent routine pregnancy test into the control group. Total protein (TP), albumin (Alb), blood urea nitrogen (BUN), uric acid (UA), creatinine (SCr), β2-microglobulin (β2-MG), α1-microglobulin (α1-MG), serum cystatin C (Cys C), lactate dehydrogenase (LDH) and other biochemical indicators were detected in the two groups. Serum IFI16, endothelin-1 (ET-1), anti-endothelial cell antibody (AECA) and the level of leptin (LP) were also detected. And then interactions between serum IFI16 and each indicator were analyzed. At last, the receiver operating characteristic (ROC) curve was used to evaluate the effect of serum IFI16 on forecasting preeclampsia.

Results: Levels of IFI16, ET-1, AECA and leptin in the research group were significantly promoted with significant differences (P<0.05). Serum IFI16 levels in PE pregnant women were positively correlated with SBP, DBP, 24h urine protein quantitation, ET-1, AECA, and leptin levels (r= 0.654, 0.435, 0.701, 0.563, 0.574, 0.561, P<0.01), respectively, negatively with Alb. (r= -0.398, P <0.01). The serum IFI16 concentration was 14.47 ng/ml, and the sensitivity and specificity of predicting PE were both 92%.

Conclusion: The elevated serum IFI16 level is associated with the onset of preeclampsia and can be used to predict the occurrence of preeclampsia.

Keywords: Serum IFI16, ET-1, AECA, Leptin, Preeclampsia, Correlation.